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What is the Entourage Effect and How Does it Work?


Now that the Louisiana medical marijuana program is fully established, there is so much to choose from! We have seen this program grow from a small one to a pretty progressive medical marijuana program.


With so many different strains, products and concentration levels to choose from, Louisianians need to know that many of these marijuana components actually work together to be the right treatment for you!


In today’s article, we will be going over the history of the entourage effect, what it is and how it works!


The History Behind the Entourage Effect

Back in the early 1960’s, a chemist from Israel named Raphael Mechoulam started to be interested in the chemical compounds that were in marijuana plants. He noticed that in other drugs such as morphine or cocaine, there were compounds that were isolated but with cannabis, there were not.


Mechoulam began his research by using marijuana samples from his local police station. After a few years of studying he found the chemical compound cannabidiol, otherwise known as CBD! A year later he was the first person to isolate delta-9-tetrahydrocannabinol, also known as THC. Mechoulam’s work led to further research in which he discovered the first natural cannabinoid that is in the brain called anandamide.


With all of these big findings, you can now see why Mechoulam is known as the Father of Cannabis Research!


In 1998, Mechoulam wrote a big research paper on what he coined as the entourage effects of marijuana!


What is the Entourage Effect?

In Mechoulam’s research paper, he revealed a phenomenon called the entourage effect. The entourage effect is when two chemical compounds work together with one enhancing the effects of the other! While one compound is binding to a receptor, another compound assists the first in the binding process.


Mechoulam found that chemical compounds in marijuana work together to create better results then with one isolated compound alone. This is the beauty of the entourage effect. The compounds work together to basically make one super compound!


How Does the Entourage Effect Work?

There are many different components of the entourage effect that you should know!


First, CBD and THC can produce an entourage effect. CBD actually acts as a buffer of some of the negative side effects that can come with THC such as anxiety or paranoia. This means that if you use them together, they will work more effectively!


Another component that is important in the entourage effect are the terpenes that are found in certain strains of medical marijuana. Terpenes are what gives the plant strain a specific taste, flavor and smell. They have their own medicinal properties that can help treat medical conditions.


You can think of terpenes as the funnel of THC. Terpenes can funnel the type of “high” that you are going to experience. Specific terpenes can make you feel sleepy, focused, hungry and much more!


CBD, THC and terpenes all work together to make medical marijuana the powerful medicine that it is!


Ready To Try The Entourage Effect?

Does it sound like medical marijuana could be right for you? If so, we are here to help!


If you have been diagnosed with a medical condition, you could potentially qualify for medical marijuana treatment in the state of Louisiana. All you need to do is have a medical condition, proof of residency and an official written certification from a Louisiana marijuana doctor. This is where we come in!


You can get your card with us in three easy steps:

  1. Schedule a telemedicine appointment by calling us at (833) 253-2943 or making your appointment online.

  2. Meet virtually with one of our certified physicians through telemedicine to discuss your medical history.

  3. With the doctor's approval, you'll receive your recommendation from the Louisiana Board of Pharmacy and be able to access any dispensary in the state!


Get the relief you deserve today with us!



Doctors Who Care. Relief You Can Trust.

At Louisiana Marijuana Card, our mission is helping everyone achieve wellness safely and conveniently through increased access to medical marijuana. Our focus on education, inclusion, and acceptance will reduce stigma for our patients by providing equal access to timely information and compassionate care.


Call us at (833) 253-2943, or simply book a medical marijuana evaluation to start getting relief you can trust today!


Check out Louisiana Marijuana Card’s Blog to keep up to date on the latest medical marijuana news, tips, and information. Follow us on Facebook, Twitter, and Instagram to join the medical marijuana conversation in Louisiana!


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